Cerebral Vascular Biology

15th International conference

June 29-July 2, 2025
Ann Arbor, MI, USA

CVB2025

PRELIMINARY PROGRAM

 

Keynote talks are 25 + 5 min, Invited talks are 15+5 min, Short Talks are 10+5 min 

DAY 1 (SUNDAY, JUNE 29th) AFTERNOON (LOCATION: MICHIGAN LEAGUE).  

 

2.00 – 3.00 PM                     

Introduction

Chair: Tom Davis

Keynote: Lester Drewes. 33 Years of Cerebral Vascular Biology: Milestones and Challenges

Keynote: Britta Engelhardt. Advancing our understanding on the role of the brain barriers in maintaining CNS immune privilege

 

3.00-5.30 PM.

Session 1: Barrier Cell Biology. (In honor of Joan Abbott/Maria Spatz)

Chairs: Chenghua Gu + TBD

  1. Keynote speaker: Matthew Campbell. Regulation of claudin-5 at the blood brain barrier in health and disease.

Invited speakers:

  1. Yao Yao. Endothelial laminin and the blood-brain barrier integrity
  2. Natasha O’Brown. Neurovascular interactions in the development of the zebrafish BBB.
  3. Lara Ogunshola. Synergy versus specialization at the blood-brain barrier.

Short Talks:

  • Four talks selected from the abstracts.

5.30-5.45 PM

In Memoriam: Joan Abbott, Bill Pardridge, Maria Spatz, Danica Stanimirovic.

 

6.00-8.00 PM.

RECEPTION (LOCATION: MICHIGAN LEAGUE)

 

 

DAY 2 (MONDAY, JUNE 30th) MORNING (LOCATION: MICHIGAN UNION).

8.30 – 11.45 AM

Session 2: Barrier/NVU in Aging and Neurodegeneration.

Chairs: Bjoern Bauer + TBD

  1. Keynote speaker: Nabil Alkayed Novel therapeutic targets for vascular cognitive impairment and dementia (VCID)

Invited Speakers

  1. Anika Hartz. Blood-brain barrier repair to improve cognition in Alzheimer’s disease
  2. TBD
  3. Sherry Hsiang-Yi Chou. ARIA and amyloid-targeting therapies: real-world challenges in acute cardiovascular and cerebrovascular emergencies

 

10.00-10.20 AM COFFEE BREAK

 

Invited speaker

  1. Sidney Strickland The possible role of the plasma contact system in ARIA

Short Talks:

  • Four talks selected from the abstracts.

 

12.00-1.00 PM MONDAY LUNCH and Special Session: New Microfluidic Devices to Model the BBB

10 min invited talks and 20 min roundtable.

Chair: Eric Shusta

  1. Luca Cucullo. Strategies in Neurovascular In Vitro Modeling: a microfluidic perspective.
  2. Dan Ahmad. The Fluidic µSiM-BBB: The Next Step in a Determined Effort to Model the Vulnerable Brain On-a-Chip 
  3. Maria Deli. TBD
  4. Brian O’Grady. Engineering Next-Gen BBB Models: A Novel Microfluidic Approach for Vascular Research

 

DAY 2 (MONDAY) AFTERNOON  (LOCATION: MICHIGAN UNION).

1.10-3.15 PM

Session 3: Barrier/NVU  in Neurological and Metabolic Diseases

Chairs: Ulf Eriksson + Dionna Williams

Invited speakers:

  1. Alon Friedman. The blood-brain barrier in traumatic brain injury: from bench to bed
  2. Ingrid Nilsson. Thrombolysis exacerbates cerebrovascular injury after ischemic stroke via a VEGF-B dependent adipose-brain metabolic axis
  3. Yuri Persidsky. Alcohol induced injury of neurovascular unit: Mechanisms and protective strategies
  4. Pedro Lowenstein. TBD

Short Talks

  • Three talks selected from the abstracts.

3.15-5.15 PM TEA BREAK +POSTER SESSION

 

FREE EVENING

 

DAY 3 (TUESDAY, JULY 1st ) MORNING (LOCATION: MICHIGAN UNION).

8.30-10.10 AM

Session 4: Preventing and Repairing NVU Dysfunction.

Chairs: Tom Arnold; TBD

Invited Speakers

  1. Linda Fredriksson. Targeting myofibroblast expansion in ischemic stroke
  2. Roman Giger. Protecting the Inflamed Vasculature to Enhance Immune-Mediated Retinal Ganglion Cell Regeneration.
  3. Michael Taylor. TBD
    • Two short talks selected from abstracts.

 

10.10 -10.30 AM Tea Break

 

10.30 AM – 12.00PM

Session 5: Other CNS Barriers.

Chairs: Peter Westenskow; TBD

Invited Speakers

  1. Nanna MacAuley. Choroid plexus as the brain’s fluid faucet
  2. Julie Siegenthaler. Meningeal barriers in development, health and disease
  3. Elia Duh. Role of microglia in inner blood-retinal barrier breakdown in ischemic retinopathy:  modulation of the neurovascular unit
    • Two short talks selected from the abstracts.

 

12.00-1.00PM. LUNCH and IBBS Membership Meeting/ Selection CVB 2029

 

DAY 3 (TUESDAY) afternoon (Location: MICHIGAN UNION).

1.00 – 3.00 PM

Session 6: Novel methods for assessing BBB/NVU

Chairs: Sumio Ohtsuki; TBD

Invited Speakers

  1. Audrey Cleuren. Mapping the blood-brain barrier one cell(type) at a time.
  2. Yang Xiao. Spatial Proteomics Builds an Atlas of the Human Hippocampus at Single-Cell Resolution.
  3. Peter Searson. Influence of risk factors for diseases of the brain on blood-brain barrier dysfunction.
    • Four short talks selected from the abstracts

 

3.00-5.00 PM

TEA BREAK + POSTER SESSION

 

CONFERENCE BANQUET (LOCATION: HENRY FORD MUSEUM)

Buses leave 5.30-6.00 PM

 

 

DAY 4 (WEDNESDAY, JULY 2nd) morning (LOCATION: MICHIGAN UNION).

8.30 AM – 11.50 AM

Session 7: Drug Delivery to the CNS (in honor of Bill Pardridge/Danica Stanimirovic).

Chairs: Xavier Declèves; Colin Greineder

Keynote speaker:

  1. Keynote speaker: Jens Niewoehner. Mechanistic and safety aspects of the Brainshuttle (TM)”

Invited speakers:

  1. Robert Thorne. ‘Enabling efficient transport of antibodies, enzymes, oligonucleotides and other proteins across the blood-brain barrier with engineered transport vehicles.
  2. Patrick Ronaldson. Transporters at the neurovascular unit: opportunities for drug delivery and therapeutic development.
  3. Irena Loryan. Oxycodone transport across brain barriers in endotoxemia: Insights from microdialysis in rats and pigs.

 

10.00- 10.30 AM TEA BREAK

 

Invited speakers

  1. Hien Zhao. Antisense oligonucleotides for the treatment of neurological diseases.

6-9.             Four short talks selected from the abstracts

 

YOUNG INVESTIGATOR AWARDS

12.00-1.00 PM. LUNCH

 

DAY 4 (Wednesday) Afternoon (LOCATION: MICHIGAN UNION).

1:00 – 2:50 PM

Session 8: Genetics/Epigenetics of Barrier Dysfunction/Vascular Malformations.

Chairs: Raina Bendayan; TBD

Invited speakers:

  1. Chris Greene. The asymmetrical barrier – deciphering brain region vulnerability to trauma
  2. Douglas Germline and somatic mutations fuel the development of Cerebral Cavernous Malformations
  3. Peetra Magnusson. Cavernoma profiling for biomarkers and potential treatments
  4. Miguel Alejandro Lopez-Ramirez. Molecular Mechanisms of Inflammation and Thrombosis in Brain Vascular Malformations.
    • Two short talks selected from the abstracts

 

2:50 PM CLOSING REMARKS

Contact

E-mail: CVBUM2025@umich.edu