PRELIMINARY PROGRAM

Keynote talks are 25 + 5 min, Invited talks are 15+5 min, Short Talks are 10+5 min

DAY 1 (SUNDAY, JUNE 29th) AFTERNOON (LOCATION: MICHIGAN LEAGUE).

2.00 – 3.00 PM
Introduction
Keynote: Lester Drewes. Cerebral Vascular Biology (CVB) after 33 years.
Keynote: Britta Engelhardt. Advancing our understanding on the role of the brain barriers in maintaining CNS immune privilege

3.00-5.30 PM.
Session 1: Barrier cell biology.
1. Keynote speaker: Matthew Campbell. Regulation of claudin-5 at the blood brain barrier in health and disease.
Invited speakers:
2. Yao Yao. Endothelial laminin and the blood-brain barrier integrity
3. Natasha O’Brown. Neurovascular interactions in the development of the zebrafish BBB.
4. Lara Ogunshola. Synergy versus specialization at the blood-brain barrier.
Short Talks:
5-8. Four talks selected from the abstracts.

6.00-8.00 PM.
RECEPTION (LOCATION: MICHIGAN LEAGUE)

DAY 2 (MONDAY, JUNE 30th) MORNING (LOCATION: MICHIGAN UNION).

8.30 – 11.45 AM
Session 2: Barrier/NVU in Aging and neurodegeneration.
1. Keynote speaker: Nabil Alkayed Novel Therapeutic Targets for Vascular Cognitive Impairment and Dementia (VCID)
Invited Speakers
2. Anika Hartz. TBD
3. Stefan Liebner. The Wnt/β-catenin pathway is modulated at the neurovascular unit in Alzheimer’s disease.
4. Sherry Hsiang-Yi Chou. Amyloid-related imaging Abnormalities (ARIA) in amyloid-targeting therapies.

10.00-10.20 AM COFFEE BREAK

Invited speaker
5. Sid Strickland The possible role of the plasma contact system in ARIA
Short Talks:
6-9. Four talks selected from the abstracts.

12.00-1.00 PM MONDAY LUNCH and Special Session: New Microfluidic Devices to Model the BBB
10 min invited talks and 20 min roundtable.
1. Luca Cucullo. TBD
2. James McGrath. The Fluidic µSiM-BBB: The Next Step in a Determined Effort to Model the Vulnerable Brain On-a-Chip
3. Maria Deli. TBD
4. Brian O’Grady. TBD

DAY 2 (MONDAY) AFTERNOON (LOCATION: MICHIGAN UNION).
1.10-3.15 PM
Session 3: Barrier/NVU in neurological and metabolic diseases
Invited speakers:
1. Alon Friedman. TBD
2. Ingrid Nielsson. Thrombolysis exacerbates cerebrovascular injury after ischemic stroke via a VEGF-B dependent adipose-brain metabolic axis
3. Yuri Persidsky. TBD
4. Pedro Lowenstein. TBD
Short Talks
5-7. Three talks selected from the abstracts.

3.15-5.15 PM TEA BREAK +POSTER SESSION

FREE EVENING

DAY 3 (TUESDAY, JULY 1st ) MORNING (LOCATION: MICHIGAN UNION).

8.30-10.10 AM
Session 4: Preventing and repairing NVU dysfunction.
Invited Speakers
1. Linda Fredriksson. Targeting myofibroblast expansion in ischemic stroke
2. Roman Giger. Protecting the Inflamed Vasculature to Enhance Immune-Mediated Retinal Ganglion Cell Regeneration.
3. Michael Taylor. TBD
4-5. Two short talks selected from abstracts.

10.10 -10.30 AM Tea Break

10.30 AM – 12.00 PM Session 5: Other CNS barriers.
Invited Speakers
1. Nanna MacAuley. Choroid plexus as the brain’s fluid faucet
2. Julie Siegenthaler. Meningeal barriers in development, health and disease
3. Elia Duh. Role of microglia in inner blood-retinal barrier breakdown in ischemic retinopathy: modulation of the neurovascular unit
4-5. Two short talks selected from the abstracts.

12.00-1.00PM. LUNCH and IBBS Membership Meeting/ Selection CVB 2029

DAY 3 (TUESDAY) afternoon (Location: MICHIGAN UNION).

1.00 – 3.00 PM Session 6: Novel methods for assessing BBB/NVU
Invited Speakers
1. Audrey Cleuren. Mapping the blood-brain barrier one cell(type) at a time.
2. Yang Xiao. Spatial Proteomics Builds an Atlas of the Human Hippocampus at Single-Cell Resolution.
3. Peter Searson. TBD
4-7. Four short talks selected from the abstracts

3.00-5.00 PM
TEA BREAK + POSTER SESSION

CONFERENCE BANQUET (LOCATION: HENRY FORD MUSEUM)
Buses leave 5.30-6.00 PM

DAY 4 (WEDNESDAY, JULY 2nd) morning (LOCATION: MICHIGAN UNION).

8.30 AM – 11.50 AM
Session 7: Drug delivery to the CNS.
Keynote speaker:
1. Keynote speaker: Jens Niewoehner. Mechanistic and safety aspects of the Brainshuttle (TM)”
Invited speakers:
2. Robert Thorne. TBD
3. Patrick Ronaldson. Blood-Brain Barrier Transporters: Overcoming “Leak” for Effective Drug Delivery in Stroke
4. Irena Loryan. Oxycodone transport across brain barriers in endotoxemia: Insights from microdialysis in rats and pigs.

10.00- 10.30 AM TEA BREAK

Invited speakers
5. Hien Zhao. Antisense oligonucleotides for the treatment of neurological diseases.
6-9. Four short talks selected from the abstracts

YOUNG INVESTIGATOR AWARDS

12.00-1.00 PM. LUNCH

DAY 4 (Wednesday) Afternoon (LOCATION: MICHIGAN UNION).

1:00 – 2:50 PM
Session 8: Genetics/epigenetics of barrier dysfunction/vascular malformations.
Invited speakers:
1. Chris Greene. The asymmetrical barrier – deciphering brain region vulnerability to trauma
2. Douglas Marchuk. Germline and somatic mutations fuel the development of Cerebral Cavernous Malformations
3. Peetra Magnusson. TBD
4. Miguel Alejandro Lopez-Ramirez. Molecular Mechanisms of Inflammation and Thrombosis in Brain Vascular Malformations.
5-6. Two short talks selected from the abstracts

2:50 PM CLOSING REMARKS